Glucocorticoid Receptor Modulator

Glucocorticoid Receptor Modulators (32):

Cat. No.	Product Name	Effect	Purity

HY-14930A

Mirodenafil dihydrochloride	Modulator	99.85%
Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc).

HY-111490

Desisobutyryl-ciclesonide	Modulator	99.77%
Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor.

HY-120012

Mizacorat	Modulator	99.71%
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC₅₀ of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation.

HY-13571

Betamethasone dipropionate	Modulator	99.40%
Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.

HY-108243

AZD5423	Modulator	99.85%
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma.

HY-14930

Mirodenafil	Modulator	99.88%
Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc).

HY-111453

Velsecorat	Modulator	99.83%
AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC₅₀ of 0.9 nM.

HY-132811

Dazucorilant	Modulator	98.91%
Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a K_i value ＜1 nM in vitro. Dazucorilant can be used for the research of neurological disorders.

HY-146564A

HP210	Modulator	98.96%
HP210 is a selective glucocorticoid receptor modulator (SGRM). HP210 can inhibit the mRNA expression of IL-1β and IL-6. HP210 has the potential to study inflammation-related diseases.

HY-151876

Glucocorticoid receptor modulator 1	Modulator	99.79%
Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC₅₀ value of 9 nM and 130 nM for NF-κB and AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice.

HY-125096

C108297	Modulator	99.97%
C108297 is a selective glucocorticoid receptor (GR) modulator (GR binding K_i 0.7 nM; GR reporter gene functional K_i 0.6 nM). C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation.

HY-U00098

Prednisolone Tebutate	Modulator	99.82%
Prednisolone tebutate is a synthetic glucocorticoid used as an antiinflammatory and immunosuppressant.

HY-U00298

Amebucort	Modulator	≥99.0%
Amebucort is a synthetic glucocorticoid corticosteroid, may used for the research of inflammatory disorders.

HY-139556

Zavacorilant	Modulator
Zavacorilant is capable of modulating glucocorticoid receptor (GR).

HY-146561

S-HP210	Modulator	98.12%
S-HP210 is a potent and selective glucocorticoid receptor (GR) with an IC₅₀ value of 1.92 μM for NF-κB transrepression (TR). S-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. S-HP210 is nontoxic at effective doses against mouse fibroblasts 3T3 cells.

HY-13571S

Betamethasone dipropionate-d₁₀	Modulator
Betamethasone dipropionate-d₁₀ is the deuterium labeled Betamethasone dipropionate. Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.

HY-149165

Glucocorticoid receptor modulator 2	Modulator	99.84%
Glucocorticoid receptor modulator 2 (Example 1) is a glucocorticoid receptor modulator, with an IC₅₀ value less than 100 nM. Glucocorticoid receptor modulator 2 can be used for research of inflammatory and immune diseases.

HY-117965

Miricorilant	Modulator
Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders.

HY-N12744

2-O-trans-p-Coumaroylalphitolic acid	Modulator
2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity.

HY-14930R

Mirodenafil (Standard)	Modulator
Mirodenafil (Standard) is the analytical standard of Mirodenafil. This product is intended for research and analytical applications. Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc).

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